› 1tc8

X-ray diffraction
2.7Å resolution

Crystal structure of Krait-venom phospholipase A2 in a complex with a natural fatty acid tridecanoic acid

Released:
DOI: 10.2210/pdb1tc8/pdb
PDB entry 1tc8 coloured by chain, front view.
PDB entry 1tc8 coloured by chain, side view.
PDB entry 1tc8 coloured by chain, top view.
Source organism: Bungarus caeruleus
Primary publication:
Crystal structure of the complex formed between a group I phospholipase A2 and a naturally occurring fatty acid at 2.7 A resolution.
Singh G, Jasti J, Saravanan K, Sharma S, Kaur P, Srinivasan A, Singh TP
Protein Sci 14 395-400 (2005)
PMID: 15659372

Function and Biology Details

Reaction catalysed: 
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180332 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acidic phospholipase A2 1 Chain: A
Molecule details ›
Chain: A
Length: 118 amino acids
Theoretical weight: 13.21 KDa
Source organism: Bungarus caeruleus
UniProt:
  • Canonical: Q6SLM2 (Residues: 20-137; Coverage: 94%)
Sequence domains: Phospholipase A2
Structure domains: Phospholipase A2 domain

Ligands and Environments

2 bound ligands:
Ligand NA 1 x NA
Ligand TDA 1 x TDA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P41212
Unit cell:
a: 53.79Å b: 53.79Å c: 82.5Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.209 0.204 0.233

Quick links

Citations

2 review citations

Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis.
Kang et al. (2011)
1 more

1 mention without citation

Crystal structure of the complex formed between a group I phospholipase A2 and a naturally occurring fatty acid at 2.7 A resolution.
Singh et al. (2005)