› 1tcf

X-ray diffraction
1.9Å resolution

CRYSTAL STRUCTURE OF CALCIUM-SATURATED RABBIT SKELETAL TROPONIN C

Released:
DOI: 10.2210/pdb1tcf/pdb
PDB entry 1tcf coloured by chain, front view.
PDB entry 1tcf coloured by chain, side view.
PDB entry 1tcf coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Conformational variation of calcium-bound troponin C.
Soman J, Tao T, Phillips GN
Proteins 37 510-1 (1999)
PMID: 10651267

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135938 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Troponin C, skeletal muscle Chain: A
Molecule details ›
Chain: A
Length: 159 amino acids
Theoretical weight: 17.99 KDa
Source organism: Oryctolagus cuniculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P02586 (Residues: 2-160; Coverage: 99%)
Gene name: TNNC2
Sequence domains: EF-hand domain pair
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 5 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SIEMENS
Spacegroup: P21
Unit cell:
a: 32.1Å b: 59.6Å c: 48Å
α: 90° β: 101.1° γ: 90°
R-values:
R R work R free
0.278 0.278 0.358
Expression system: Escherichia coli

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Citations

1 review citation

The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitiser, with cardiac troponin c.
Sorsa et al. (2004)
10 other articles

6 mentions without citation

FATCAT 2.0: towards a better understanding of the structural diversity of proteins.
Li et al. (2020)
5 more