› 1tfj

X-ray diffraction
1.61Å resolution

Crystal structure of Bovine Glycolipid transfer protein in complex with a fatty acid

Released:
DOI: 10.2210/pdb1tfj/pdb
PDB entry 1tfj coloured by chain, front view.
PDB entry 1tfj coloured by chain, side view.
PDB entry 1tfj coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Structural evidence for adaptive ligand binding of glycolipid transfer protein.
Airenne TT, Kidron H, Nymalm Y, Nylund M, West G, Mattjus P, Salminen TA
J Mol Biol 355 224-36 (2006)
PMID: 16309699

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159365 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycolipid transfer protein Chain: A
Molecule details ›
Chain: A
Length: 219 amino acids
Theoretical weight: 25.09 KDa
Source organism: Bos taurus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P68265 (Residues: 2-209; Coverage: 100%)
Gene name: GLTP
Sequence domains: Glycolipid transfer protein (GLTP)
Structure domains: Glycolipid transfer protein

Ligands and Environments

3 bound ligands:
Ligand CL 1 x CL
Ligand DKA 1 x DKA
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P21
Unit cell:
a: 55.395Å b: 34.904Å c: 58.168Å
α: 90° β: 116.16° γ: 90°
R-values:
R R work R free
0.184 0.182 0.221
Expression system: Escherichia coli BL21

Quick links

Citations

7 review citations

Glycolipid transfer proteins.
Brown et al. (2007)
6 more

1 mention without citation

Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitors.
Xie et al. (2009)