› 1tfs

Solution NMR

NMR AND RESTRAINED MOLECULAR DYNAMICS STUDY OF THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF TOXIN FS2, A SPECIFIC BLOCKER OF THE L-TYPE CALCIUM CHANNEL, ISOLATED FROM BLACK MAMBA VENOM

Released:
DOI: 10.2210/pdb1tfs/pdb
PDB entry 1tfs coloured by chain, ensemble of 20 models, front view.
PDB entry 1tfs coloured by chain, ensemble of 20 models, side view.
PDB entry 1tfs coloured by chain, ensemble of 20 models, top view.
Source organism: Dendroaspis polylepis polylepis
Primary publication:
NMR and restrained molecular dynamics study of the three-dimensional solution structure of toxin FS2, a specific blocker of the L-type calcium channel, isolated from black mamba venom.
Albrand JP, Blackledge MJ, Pascaud F, Hollecker M, Marion D
Biochemistry 34 5923-37 (1995)
PMID: 7727450

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134308 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toxin FS-2 Chain: A
Molecule details ›
Chain: A
Length: 60 amino acids
Theoretical weight: 7.04 KDa
Source organism: Dendroaspis polylepis polylepis
Expression system: Not provided
UniProt:
  • Canonical: P01414 (Residues: 1-60; Coverage: 100%)
Structure domains: CD59

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

9 review citations

Snake venom alpha-neurotoxins and other 'three-finger' proteins.
Tsetlin V. (1999)
8 more

3 mentions without citation

The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential.
Zamponi et al. (2015)
2 more