› 1tgb

X-ray diffraction
1.8Å resolution

CRYSTAL STRUCTURE OF BOVINE TRYPSINOGEN AT 1.8 ANGSTROMS RESOLUTION. II. CRYSTALLOGRAPHIC REFINEMENT, REFINED CRYSTAL STRUCTURE AND COMPARISON WITH BOVINE TRYPSIN

Released:
DOI: 10.2210/pdb1tgb/pdb
PDB entry 1tgb coloured by chain, front view.
PDB entry 1tgb coloured by chain, side view.
PDB entry 1tgb coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Crystal structure of bovine trypsinogen at 1-8 A resolution. II. Crystallographic refinement, refined crystal structure and comparison with bovine trypsin.
Fehlhammer H, Bode W, Huber R
J Mol Biol 111 415-38 (1977)
PMID: 864704

Function and Biology Details

Reaction catalysed: 
Preferential cleavage: Arg-|-, Lys-|-.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133319 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease 1 Chain: A
Molecule details ›
Chain: A
Length: 229 amino acids
Theoretical weight: 24.01 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: P00760 (Residues: 18-246; Coverage: 100%)
Gene names: PRSS1, TRP1, TRY1, TRYP1
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3121
Unit cell:
a: 55.1Å b: 55.1Å c: 109.4Å
α: 90° β: 90° γ: 120°
Expression system: Not provided

Quick links

Citations

12 review citations

Natural protein proteinase inhibitors and their interaction with proteinases.
Bode et al. (1992)
11 more

6 mentions without citation

Allostery in trypsin-like proteases suggests new therapeutic strategies.
Gohara et al. (2011)
5 more