› 1tmc

X-ray diffraction
2.3Å resolution

THE THREE-DIMENSIONAL STRUCTURE OF A CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE MISSING THE ALPHA3 DOMAIN OF THE HEAVY CHAIN

Released:
DOI: 10.2210/pdb1tmc/pdb
Model geometry
Fit model/data
Data not analysed
PDB entry 1tmc coloured by chain, front view.
PDB entry 1tmc coloured by chain, side view.
PDB entry 1tmc coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain.
Collins EJ, Garboczi DN, Karpusas MN, Wiley DC
Proc Natl Acad Sci U S A 92 1218-21 (1995)
PMID: 7862664

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-137733 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, A alpha chain Chain: A
Molecule details ›
Chain: A
Length: 175 amino acids
Theoretical weight: 20.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-199; Coverage: 51%)
Gene names: HLA-A, HLAA
Sequence domains: Class I Histocompatibility antigen, domains alpha 1 and 2
Structure domains: MHC class I-like antigen recognition-like
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
DECAMERIC PEPTIDE (EVAPPEYHRK) Chain: C

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
Spacegroup: P212121
Unit cell:
a: 48.23Å b: 58.05Å c: 109.53Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.207 not available
Expression system: Escherichia coli

Quick links

Citations

6 review citations

MHC superfamily structure and the immune system.
Maenaka et al. (1999)
5 more

3 mentions without citation

Modeling the structure of bound peptide ligands to major histocompatibility complex.
Tong et al. (2004)
2 more