› 1tpz

X-ray diffraction
2Å resolution

Crystal Structure of IIGP1: a paradigm for interferon inducible p47 resistance GTPases

Released:
DOI: 10.2210/pdb1tpz/pdb
PDB entry 1tpz coloured by chain, front view.
PDB entry 1tpz coloured by chain, side view.
PDB entry 1tpz coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases.
Ghosh A, Uthaiah R, Howard J, Herrmann C, Wolf E
Mol Cell 15 727-39 (2004)
PMID: 15350217

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193063 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon-inducible GTPase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 422 amino acids
Theoretical weight: 48.72 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9QZ85 (Residues: 1-411; Coverage: 100%)
Gene names: Iigp1, Irga6
Sequence domains: Interferon-inducible GTPase (IIGP)
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

4 bound ligands:
Ligand MG 2 x MG
Ligand GDP 2 x GDP
Ligand EDO 1 x EDO
Ligand MPD 1 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 80.54Å b: 91.89Å c: 143.47Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.235 0.208 0.241
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

19 review citations

Structure-function relationships of the G domain, a canonical switch motif.
Wittinghofer et al. (2011)
18 more

6 mentions without citation

A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins.
Fleckenstein et al. (2012)
5 more