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X-ray diffraction
2.03Å resolution

Golgi alpha-Mannosidase II In Complex With The Salacinol Analog Ghavamiol

Released:
DOI: 10.2210/pdb1tqu/pdb
Model geometry
Fit model/data
PDB entry 1tqu coloured by chain, front view.
PDB entry 1tqu coloured by chain, side view.
PDB entry 1tqu coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Crystallographic analysis of the interactions of Drosophila melanogaster Golgi alpha-mannosidase II with the naturally occurring glycomimetic salacinol and its analogues
Kuntz DA, Ghavami A, Johnston BD, Pinto BM, Rose DR
Tetrahedron Asymmetry 16 25-32 (2005)

Function and Biology Details

Reaction catalysed: 
N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 2 H2O = 2 alpha-D-mannopyranose+ an N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein].
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173193 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

4 bound ligands:
Ligand NAG 1 x NAG
Ligand ZN 1 x ZN
Ligand GHA 1 x GHA
Ligand MRD 1 x MRD
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 68.298Å b: 108.957Å c: 137.723Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.132 0.132 0.182
Expression system: Drosophila melanogaster

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