› 1tv0

Solution NMR

Solution structure of cryptdin-4, the most potent alpha-defensin from mouse Paneth cells

Released:
DOI: 10.2210/pdb1tv0/pdb
PDB entry 1tv0 coloured by chain, ensemble of 20 models, front view.
PDB entry 1tv0 coloured by chain, ensemble of 20 models, side view.
PDB entry 1tv0 coloured by chain, ensemble of 20 models, top view.
Source organism: Mus musculus
Primary publication:
Solution structure of cryptdin-4, a mouse paneth cell alpha-defensin.
Jing W, Hunter HN, Tanabe H, Ouellette AJ, Vogel HJ
Biochemistry 43 15759-66 (2004)
PMID: 15595831

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151199 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Defensin alpha 4 Chain: A
Molecule details ›
Chain: A
Length: 32 amino acids
Theoretical weight: 3.77 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P28311 (Residues: 61-92; Coverage: 44%)
Gene names: Defa4, Defcr4

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Paneth cell α-defensins in enteric innate immunity.
Ouellette AJ. (2011)
4 more

3 mentions without citation

New Disulfide-Stabilized Fold Provides Sea Anemone Peptide to Exhibit Both Antimicrobial and TRPA1 Potentiating Properties.
Logashina et al. (2017)
2 more