› 1tvk

Electron crystallography
2.89Å resolution

The binding mode of epothilone A on a,b-tubulin by electron crystallography

Released:
DOI: 10.2210/pdb1tvk/pdb
PDB entry 1tvk coloured by chain, front view.
PDB entry 1tvk coloured by chain, side view.
PDB entry 1tvk coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography.
Nettles JH, Li H, Cornett B, Krahn JM, Snyder JP, Downing KH
Science 305 866-9 (2004)
PMID: 15297674

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173621 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Tubulin alpha-1D chain Chain: A
Molecule details ›
Chain: A
Length: 440 amino acids
Theoretical weight: 48.87 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q2HJ86 (Residues: 1-440; Coverage: 97%)
Gene name: TUBA1D
Sequence domains:
Structure domains:
Tubulin beta-2B chain Chain: B
Molecule details ›
Chain: B
Length: 427 amino acids
Theoretical weight: 47.94 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q6B856 (Residues: 1-427; Coverage: 96%)
Gene name: TUBB2B
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand GTP 1 x GTP
Ligand GDP 1 x GDP
Ligand EP 1 x EP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.89Å

Quick links

Citations

67 review citations

Microtubules and resistance to tubulin-binding agents.
Kavallaris M. (2010)
66 more

21 mentions without citation

Recent advances in the study of the bioactive conformation of taxol.
Sun et al. (2009)
20 more