› 1tw9

X-ray diffraction
1.71Å resolution

Glutathione Transferase-2, apo form, from the nematode Heligmosomoides polygyrus

Released:
DOI: 10.2210/pdb1tw9/pdb
PDB entry 1tw9 coloured by chain, front view.
PDB entry 1tw9 coloured by chain, side view.
PDB entry 1tw9 coloured by chain, top view.
Source organism: Heligmosomoides polygyrus
Primary publication:
Crystal structure of a new class of glutathione transferase from the model human hookworm nematode Heligmosomoides polygyrus.
Schuller DJ, Liu Q, Kriksunov IA, Campbell AM, Barrett J, Brophy PM, Hao Q
Proteins 61 1024-31 (2005)
PMID: 16189827

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192439 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutathione S-transferase 2 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 206 amino acids
Theoretical weight: 23.42 KDa
Source organism: Heligmosomoides polygyrus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NJQ6 (Residues: 1-204; Coverage: 100%)
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P1
Unit cell:
a: 72.678Å b: 74.034Å c: 88.573Å
α: 79.09° β: 80.08° γ: 81.55°
R-values:
R R work R free
0.181 0.18 0.232
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Glutathione transferases: a structural perspective.
Oakley A. (2011)
3 more

3 mentions without citation

Molecular mimicry between cockroach and helminth glutathione S-transferases promotes cross-reactivity and cross-sensitization.
Santiago et al. (2012)
2 more