› 1u01

Solution NMR

High resolution NMR structure of 5-d(GCGT*GCG)-3/5-d(CGCACGC)-3 (T*represents a cyclohexenyl nucleotide)

Released:
DOI: 10.2210/pdb1u01/pdb
PDB entry 1u01 coloured by chain, front view.
PDB entry 1u01 coloured by chain, side view.
PDB entry 1u01 coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Cyclohexenyl nucleic acids: conformationally flexible oligonucleotides.
Nauwelaerts K, Lescrinier E, Sclep G, Herdewijn P
Nucleic Acids Res 33 2452-63 (2005)
PMID: 15863723

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114666 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
5'-D(*GP*CP*GP*(XTR)P*GP*CP*G)-3' Chain: A
Molecule details ›
Chain: A
Length: 7 nucleotides
Theoretical weight: 2.16 KDa
Source organism: Synthetic construct
Expression system: Not provided
5'-D(*CP*GP*CP*AP*CP*GP*C)-3' Chain: B
Molecule details ›
Chain: B
Length: 7 nucleotides
Theoretical weight: 2.08 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
1 modified residue:
Ligand XTR 1 x XTR

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing followed by a molecular dynamics
Expression system: Not provided

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Citations

5 review citations

Non-natural nucleic acids for synthetic biology.
Appella DH. (2009)
4 more

16 mentions without citation

Idiosyncratic drug-induced liver injury is associated with substantial morbidity and mortality within 6 months from onset.
Fontana et al. (2014)
15 more