› 1u2c

X-ray diffraction
2.3Å resolution

Crystal Structure of a-dystroglycan

Released:
DOI: 10.2210/pdb1u2c/pdb
PDB entry 1u2c coloured by chain, front view.
PDB entry 1u2c coloured by chain, side view.
PDB entry 1u2c coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The structure of the N-terminal region of murine skeletal muscle alpha-dystroglycan discloses a modular architecture.
Bozic D, Sciandra F, Lamba D, Brancaccio A
J Biol Chem 279 44812-6 (2004)
PMID: 15326183

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178918 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-dystroglycan Chain: A
Molecule details ›
Chain: A
Length: 246 amino acids
Theoretical weight: 26.23 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q62165 (Residues: 58-303; Coverage: 28%)
Gene name: Dag1
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: R3
Unit cell:
a: 71.445Å b: 71.445Å c: 144.233Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.208 0.262
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Molecular evolution of the cadherin superfamily.
Hulpiau et al. (2009)
7 more

10 mentions without citation

Neurexins - versatile molecular platforms in the synaptic cleft.
Rudenko G. (2019)
9 more