› 1u3o

Solution NMR

Solution structure of rat Kalirin N-terminal SH3 domain

Released:
DOI: 10.2210/pdb1u3o/pdb
PDB entry 1u3o coloured by chain, ensemble of 20 models, front view.
PDB entry 1u3o coloured by chain, ensemble of 20 models, side view.
PDB entry 1u3o coloured by chain, ensemble of 20 models, top view.
Source organism: Rattus norvegicus
Primary publication:
Regulation of RhoGEF activity by intramolecular and intermolecular SH3 domain interactions.
Schiller MR, Chakrabarti K, King GF, Schiller NI, Eipper BA, Maciejewski MW
J Biol Chem 281 18774-86 (2006)
PMID: 16644733

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161338 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kalirin Chain: A
Molecule details ›
Chain: A
Length: 82 amino acids
Theoretical weight: 8.58 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P97924 (Residues: 1617-1686; Coverage: 2%)
Gene names: Duo, Hapip, Kalrn
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this NMR entry.
Refinement method: Torsion angle dynamics and simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

7 review citations

Symmetry breaking and the establishment of cell polarity in budding yeast.
Johnson et al. (2011)
6 more

1 mention without citation

Insight into the Mechanism of Intramolecular Inhibition of the Catalytic Activity of Sirtuin 2 (SIRT2).
Li et al. (2015)