› 1u5g

X-ray diffraction
2.1Å resolution

Crystal Structure of the PH Domain of SKAP-Hom

Released:
DOI: 10.2210/pdb1u5g/pdb
PDB entry 1u5g coloured by chain, front view.
PDB entry 1u5g coloured by chain, side view.
PDB entry 1u5g coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch.
Swanson KD, Tang Y, Ceccarelli DF, Poy F, Sliwa JP, Neel BG, Eck MJ
Mol Cell 32 564-75 (2008)
PMID: 19026786

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174848 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Src kinase-associated phosphoprotein 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 122 amino acids
Theoretical weight: 14.21 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q3UND0 (Residues: 101-222; Coverage: 34%)
Gene names: Prap, Ra70, Saps, Scap2, Skap2, Skap55r
Sequence domains: PH domain
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 59.613Å b: 65.695Å c: 143.767Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.213 0.271
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

9 review citations

Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms.
Scheffzek et al. (2012)
8 more

2 mentions without citation

The Skap-hom dimerization and PH domains comprise a 3'-phosphoinositide-gated molecular switch.
Swanson et al. (2008)
1 more