› 1u6a

X-ray diffraction
2.81Å resolution

Crystal Structure of the Broadly Neutralizing Anti-HIV Fab F105

Released:
DOI: 10.2210/pdb1u6a/pdb
PDB entry 1u6a coloured by chain, front view.
PDB entry 1u6a coloured by chain, side view.
PDB entry 1u6a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the Fab fragment of F105, a broadly reactive anti-human immunodeficiency virus (HIV) antibody that recognizes the CD4 binding site of HIV type 1 gp120.
Wilkinson RA, Piscitelli C, Teintze M, Cavacini LA, Posner MR, Lawrence CM
J Virol 79 13060-9 (2005)
PMID: 16189008

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179925 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ig-like domain-containing protein Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 23.5 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q6PIL8 (Residues: 21-236; Coverage: 100%)
Gene name: IGK@
Sequence domains:
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chain: H
Molecule details ›
Chain: H
Length: 224 amino acids
Theoretical weight: 23.76 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q6N089 (Residues: 20-126, 127-243; Coverage: 49%)
Gene name: DKFZp686P15220
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R
Spacegroup: P43212
Unit cell:
a: 120.403Å b: 120.403Å c: 72.977Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.248 0.21 0.251
Expression system: Not provided

Quick links

Citations

3 review citations

Ibalizumab Targeting CD4 Receptors, An Emerging Molecule in HIV Therapy.
Iacob et al. (2017)
2 more

5 mentions without citation

Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign.
Tran et al. (2014)
4 more