› 1u6t

X-ray diffraction
1.9Å resolution

Crystal structure of the human SH3 binding glutamic-rich protein like

Released:
DOI: 10.2210/pdb1u6t/pdb
PDB entry 1u6t coloured by chain, front view.
PDB entry 1u6t coloured by chain, side view.
PDB entry 1u6t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human SH3BGRL protein: the first structure of the human SH3BGR family representing a novel class of thioredoxin fold proteins.
Yin L, Xiang Y, Zhu DY, Yan N, Huang RH, Zhang Y, Wang DC
Proteins 61 213-6 (2005)
PMID: 16080146

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130919 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adapter SH3BGRL Chain: A
Molecule details ›
Chain: A
Length: 121 amino acids
Theoretical weight: 13.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O75368 (Residues: 2-114; Coverage: 99%)
Gene name: SH3BGRL
Sequence domains: SH3-binding, glutamic acid-rich protein
Structure domains: Glutaredoxin

Ligands and Environments

1 bound ligand:
Ligand CIT 1 x CIT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 28.886Å b: 34.815Å c: 97.965Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.168 0.168 0.212
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 citation in other articles

Proteome analysis of human substantia nigra in Parkinson's disease.
Werner et al. (2008)
5 more

2 mentions without citation

SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane.
Li et al. (2020)
1 more