› 1u8k

X-ray diffraction
2.24Å resolution

Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide LELDKWASL

Released:
DOI: 10.2210/pdb1u8k/pdb
PDB entry 1u8k coloured by chain, front view.
PDB entry 1u8k coloured by chain, side view.
PDB entry 1u8k coloured by chain, top view.
Source organisms:
Entry authors: Bryson S, Julien J-P, Pai EF

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-211577 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
ANTIBODY 2F5 (LIGHT CHAIN) Chain: A
Molecule details ›
Chain: A
Length: 214 amino acids
Theoretical weight: 23.39 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
ANTIBODY 2F5 (HEAVY CHAIN) Chain: B
Molecule details ›
Chain: B
Length: 234 amino acids
Theoretical weight: 24.9 KDa
Source organism: Homo sapiens
Structure domains: Immunoglobulins
GP41 PEPTIDE Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.08 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X8C
Spacegroup: P212121
Unit cell:
a: 57.6Å b: 64.4Å c: 174.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.215 0.246
Expression system: Not provided

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