› 1u9n

X-ray diffraction
2.3Å resolution

Crystal structure of the transcriptional regulator EthR in a ligand bound conformation opens therapeutic perspectives against tuberculosis and leprosy

Released:
DOI: 10.2210/pdb1u9n/pdb
PDB entry 1u9n coloured by chain, front view.
PDB entry 1u9n coloured by chain, side view.
PDB entry 1u9n coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Structure of EthR in a ligand bound conformation reveals therapeutic perspectives against tuberculosis.
Frénois F, Engohang-Ndong J, Locht C, Baulard AR, Villeret V
Mol Cell 16 301-7 (2004)
PMID: 15494316

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161781 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH-type transcriptional regulator EthR Chain: A
Molecule details ›
Chain: A
Length: 236 amino acids
Theoretical weight: 26.16 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P9WMC1 (Residues: 1-216; Coverage: 100%)
Gene names: Rv3855, etaR, ethR
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand CNS 1 x CNS
1 modified residue:
Ligand MSE 5 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P41212
Unit cell:
a: 122.38Å b: 122.38Å c: 33.57Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.201 0.231
Expression system: Escherichia coli BL21

Quick links

Citations

19 review citations

Antituberculosis drugs: ten years of research.
Janin YL. (2007)
18 more

5 mentions without citation

Targeting Antibiotic Resistance.
Chellat et al. (2016)
4 more