› 1uc6

Solution NMR

Solution Structure of the Carboxyl Terminal Domain of the Ciliary Neurotrophic Factor Receptor

Released:
DOI: 10.2210/pdb1uc6/pdb
PDB entry 1uc6 coloured by chain, ensemble of 21 models, front view.
PDB entry 1uc6 coloured by chain, ensemble of 21 models, side view.
PDB entry 1uc6 coloured by chain, ensemble of 21 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the C-terminal domain of the ciliary neurotrophic factor (CNTF) receptor and ligand free associations among components of the CNTF receptor complex.
Man D, He W, Sze KH, Gong K, Smith DK, Zhu G, Ip NY
J Biol Chem 278 23285-94 (2003)
PMID: 12707266

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150895 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ciliary neurotrophic factor receptor subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 12.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P26992 (Residues: 202-305; Coverage: 30%)
Gene name: CNTFR
Sequence domains: Fibronectin type III domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

5 review citations

LIF in the regulation of T-cell fate and as a potential therapeutic.
Metcalfe SM. (2011)
4 more

3 mentions without citation

Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient.
Rousseau et al. (2006)
2 more