› 1ufv

X-ray diffraction
2.05Å resolution

Crystal Structure Of Pantothenate Synthetase From Thermus Thermophilus HB8

Released:
DOI: 10.2210/pdb1ufv/pdb
Model geometry
Fit model/data
PDB entry 1ufv coloured by chain, front view.
PDB entry 1ufv coloured by chain, side view.
PDB entry 1ufv coloured by chain, top view.
Source organism: Thermus thermophilus
Entry authors: Bagautdinov B, Kuramitsu S, Yokoyama S, Miyano M, Tahirov TH, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-177868 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pantothenate synthetase Chains: A, B
Molecule details ›
Chains: A, B
Length: 276 amino acids
Theoretical weight: 30.94 KDa
Source organism: Thermus thermophilus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q5SHF5 (Residues: 1-276; Coverage: 100%)
Gene names: TTHA1775, panC
Sequence domains: Pantoate-beta-alanine ligase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CL 3 x CL
Ligand GOL 5 x GOL
1 modified residue:
Ligand MSE 10 x MSE

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SPRING-8 BEAMLINE BL26B1
Spacegroup: P6122
Unit cell:
a: 88.558Å b: 88.558Å c: 266.974Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.201 0.201 0.246
Expression system: Escherichia coli BL21(DE3)

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