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Solution NMR

SOLUTION STRUCTURE OF THE AMINO TERMINAL FRAGMENT OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR

Released:
DOI: 10.2210/pdb1urk/pdb
PDB entry 1urk coloured by chain, ensemble of 15 models, front view.
PDB entry 1urk coloured by chain, ensemble of 15 models, side view.
PDB entry 1urk coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the amino-terminal fragment of urokinase-type plasminogen activator.
Hansen AP, Petros AM, Meadows RP, Nettesheim DG, Mazar AP, Olejniczak ET, Xu RX, Pederson TM, Henkin J, Fesik SW
Biochemistry 33 4847-64 (1994)
PMID: 8161544

Function and Biology Details

Reaction catalysed: 
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133249 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Urokinase-type plasminogen activator long chain A Chain: A
Molecule details ›
Chain: A
Length: 130 amino acids
Theoretical weight: 14.72 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00749 (Residues: 26-155; Coverage: 32%)
Gene name: PLAU
Sequence domains: Kringle domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand FUC 1 x FUC
No modified residues

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

5 review citations

Structure and distribution of modules in extracellular proteins.
Bork et al. (1996)
4 more

3 mentions without citation

The Urokinase Receptor (uPAR) as a "Trojan Horse" in Targeted Cancer Therapy: Challenges and Opportunities.
Metrangolo et al. (2021)
2 more