› 1uui

Solution NMR

NMR structure of a synthetic small molecule, rbt158, bound to HIV-1 TAR RNA

Released:
DOI: 10.2210/pdb1uui/pdb
PDB entry 1uui coloured by chain, front view.
PDB entry 1uui coloured by chain, side view.
PDB entry 1uui coloured by chain, top view.
Source organism: Human immunodeficiency virus type 1 (CLONE 12)
Primary publication:
Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic "hot spots".
Davis B, Afshar M, Varani G, Murchie AI, Karn J, Lentzen G, Drysdale M, Bower J, Potter AJ, Starkey ID, Swarbrick T, Aboul-ela F
J Mol Biol 336 343-56 (2004)
PMID: 14757049

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196228 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
5'-R(*GP*GP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP*CP* CP*UP*GP*GP*GP*AP*GP*CP*UP*CP*UP*CP*UP*GP*CP*C)-3' Chain: B
Molecule details ›
Chain: B
Length: 29 nucleotides
Theoretical weight: 9.31 KDa
Source organism: Human immunodeficiency virus type 1 (CLONE 12)
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand P12 1 x P12
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: NOE-RESTRAINED DYNAMICS
Expression system: Not provided

Quick links

Citations

15 review citations

Survey of the year 2004 commercial optical biosensor literature.
Rich et al. (2005)
14 more

16 mentions without citation

Structural and computational studies of HIV-1 RNA.
Levintov et al. (2024)
15 more