› 1uzv

X-ray diffraction
1Å resolution

High affinity fucose binding of Pseudomonas aeruginosa lectin II: 1.0 A crystal structure of the complex

Released:
DOI: 10.2210/pdb1uzv/pdb
PDB entry 1uzv coloured by chain, front view.
PDB entry 1uzv coloured by chain, side view.
PDB entry 1uzv coloured by chain, top view.
Source organism: Pseudomonas aeruginosa
Primary publication:
High affinity fucose binding of Pseudomonas aeruginosa lectin PA-IIL: 1.0 A resolution crystal structure of the complex combined with thermodynamics and computational chemistry approaches.
Mitchell EP, Sabin C, Snajdrová L, Pokorná M, Perret S, Gautier C, Hofr C, Gilboa-Garber N, Koca J, Wimmerová M, Imberty A
Proteins 58 735-46 (2005)
PMID: 15573375

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-191159 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calcium-mediated lectin domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 114 amino acids
Theoretical weight: 11.73 KDa
Source organism: Pseudomonas aeruginosa
UniProt:
  • Canonical: Q9HYN5 (Residues: 2-115; Coverage: 99%)
Gene names: PA3361, lecB
Sequence domains: Fucose-binding lectin II (PA-IIL)
Structure domains: Calcium-mediated lectin

Ligands and Environments

3 bound ligands:
Ligand SO4 2 x SO4
Ligand CA 8 x CA
Ligand FUC 4 x FUC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P21
Unit cell:
a: 52.735Å b: 72.827Å c: 54.747Å
α: 90° β: 94.21° γ: 90°
R-values:
R R work R free
0.115 not available 0.135

Quick links

Citations

4 review citations

Prospects for glycoinformatics.
Pérez et al. (2005)
3 more

8 mentions without citation

Structural Considerations for Building Synthetic Glycoconjugates as Inhibitors for Pseudomonas aeruginosa Lectins.
Wojtczak et al. (2022)
7 more