› 1v0z

X-ray diffraction
1.84Å resolution

Structure of Neuraminidase from English duck subtype N6

Released:
DOI: 10.2210/pdb1v0z/pdb
PDB entry 1v0z coloured by chain, front view.
PDB entry 1v0z coloured by chain, side view.
PDB entry 1v0z coloured by chain, top view.
Source organism: Influenza A virus
Entry authors: Rudino-Pinera E, Tunnah P, Crennell SJ, Webster RG, Laver WG, Garman EF

Function and Biology Details

Reaction catalysed: 
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180538 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (6 distinct):
Neuraminidase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 389 amino acids
Theoretical weight: 43.01 KDa
Source organism: Influenza A virus
Expression system: Gallus gallus
UniProt:
  • Canonical: Q6XV27 (Residues: 82-470; Coverage: 83%)
Gene name: NA
Sequence domains: Neuraminidase
Structure domains: Neuraminidase

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, MAN, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: MAN, BMA
Carbohydrate polymer
5 bound ligands:
Ligand CA 4 x CA
Ligand GOL 4 x GOL
Ligand NAG 12 x NAG
Ligand MAN 7 x MAN
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX7.2
Spacegroup: P21
Unit cell:
a: 106.482Å b: 73.755Å c: 106.809Å
α: 90° β: 90.37° γ: 90°
R-values:
R R work R free
0.151 0.149 0.19
Expression system: Gallus gallus

Quick links