1vc4

X-ray diffraction
1.8Å resolution

Crystal Structure of Indole-3-Glycerol Phosphate Synthase (TrpC) from Thermus Thermophilus At 1.8 A Resolution

Released:
Source organism: Thermus thermophilus
Primary publication:
Structure of indole-3-glycerol phosphate synthase from Thermus thermophilus HB8: implications for thermal stability.
Acta Crystallogr D Biol Crystallogr 67 1054-64 (2011)
PMID: 22120743

Function and Biology Details

Reaction catalysed:
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO(2) + H(2)O
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
PDBe Complex ID:
PDB-CPX-160827 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
indole-3-glycerol-phosphate synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 254 amino acids
Theoretical weight: 27.45 KDa
Source organism: Thermus thermophilus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P84126 (Residues: 1-254; Coverage: 100%)
Gene name: tthHB8IM
Sequence domains: Indole-3-glycerol phosphate synthase
Structure domains: Aldolase class I

Ligands and Environments

3 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-D
Spacegroup: P212121
Unit cell:
a: 63.652Å b: 78.193Å c: 91.523Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.186 0.218
Expression system: Escherichia coli BL21(DE3)