› 1ve2

X-ray diffraction
1.8Å resolution

Crystal structure of uroporphyrin-III-C-methyltransferase from thermus thermophilus

Released:
DOI: 10.2210/pdb1ve2/pdb
PDB entry 1ve2 coloured by chain, front view.
PDB entry 1ve2 coloured by chain, side view.
PDB entry 1ve2 coloured by chain, top view.
Source organism: Thermus thermophilus
Entry authors: Jeyakanthan J, Tahirov TH, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
(1a) S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176167 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
uroporphyrinogen-III C-methyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 235 amino acids
Theoretical weight: 24.55 KDa
Source organism: Thermus thermophilus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q53WA2 (Residues: 1-235; Coverage: 100%)
Gene name: TTHB060
Sequence domains: Tetrapyrrole (Corrin/Porphyrin) Methylases
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B1
Spacegroup: P212121
Unit cell:
a: 54.609Å b: 87.924Å c: 91.602Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.207 0.241
Expression system: Escherichia coli

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