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› 1veu

X-ray diffraction
2.15Å resolution

Crystal structure of the p14/MP1 complex at 2.15 A resolution

Released:
DOI: 10.2210/pdb1veu/pdb
Model geometry
Fit model/data
PDB entry 1veu coloured by chain, front view.
PDB entry 1veu coloured by chain, side view.
PDB entry 1veu coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes.
Kurzbauer R, Teis D, de Araujo ME, Maurer-Stroh S, Eisenhaber F, Bourenkov GP, Bartunik HD, Hekman M, Rapp UR, Huber LA, Clausen T
Proc Natl Acad Sci U S A 101 10984-9 (2004)
PMID: 15263099

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131570 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ragulator complex protein LAMTOR3 Chain: A
Molecule details ›
Chain: A
Length: 124 amino acids
Theoretical weight: 13.61 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O88653 (Residues: 1-124; Coverage: 100%)
Gene names: Lamtor3, Map2k1ip1, Mapbp, Mapksp1
Sequence domains: Mitogen-activated protein kinase kinase 1 interacting
Structure domains: Dynein light chain 2a, cytoplasmic
Ragulator complex protein LAMTOR2 Chain: B
Molecule details ›
Chain: B
Length: 126 amino acids
Theoretical weight: 13.78 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9JHS3 (Residues: 1-125; Coverage: 100%)
Gene names: Lamtor2, Mapbpip, Robld3
Sequence domains: Roadblock/LC7 domain
Structure domains: Dynein light chain 2a, cytoplasmic

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 6 x MSE

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU RU300
Spacegroup: P212121
Unit cell:
a: 47.416Å b: 62.106Å c: 74.503Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.201 0.262
Expression system: Escherichia coli

Quick links

Citations

21 review citations

ERK1/2 MAP kinases: structure, function, and regulation.
Roskoski R. (2012)
20 more

4 mentions without citation

Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes.
Kurzbauer et al. (2004)
3 more