› 1vf7

X-ray diffraction
2.4Å resolution

Crystal structure of the membrane fusion protein, MexA of the multidrug transporter

Released:
DOI: 10.2210/pdb1vf7/pdb
PDB entry 1vf7 coloured by chain, front view.
PDB entry 1vf7 coloured by chain, side view.
PDB entry 1vf7 coloured by chain, top view.
Source organism: Pseudomonas aeruginosa
Primary publication:
Crystal structure of the membrane fusion protein, MexA, of the multidrug transporter in Pseudomonas aeruginosa.
Akama H, Matsuura T, Kashiwagi S, Yoneyama H, Narita S, Tsukihara T, Nakagawa A, Nakae T
J Biol Chem 279 25939-42 (2004)
PMID: 15117957

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tridecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156553 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Multidrug resistance protein MexA Chains: A, B, C, D, E, F, G, H, I, J, K, L, M
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M
Length: 369 amino acids
Theoretical weight: 39.73 KDa
Source organism: Pseudomonas aeruginosa
Expression system: Pseudomonas aeruginosa
UniProt:
  • Canonical: P52477 (Residues: 25-383; Coverage: 100%)
Gene names: PA0425, mexA
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P21
Unit cell:
a: 130.03Å b: 180.35Å c: 214.23Å
α: 90° β: 106.99° γ: 90°
R-values:
R R work R free
0.259 0.258 0.282
Expression system: Pseudomonas aeruginosa

Quick links

Citations

44 review citations

Structure, function, and evolution of bacterial ATP-binding cassette systems.
Davidson et al. (2008)
43 more

8 mentions without citation

Carbapenems: past, present, and future.
Papp-Wallace et al. (2011)
7 more