› 1vg1

X-ray diffraction
1.9Å resolution

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140684 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related protein Rab-7a Chain: A
Molecule details ›
Chain: A
Length: 185 amino acids
Theoretical weight: 21.12 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09527 (Residues: 1-185; Coverage: 89%)
Gene names: Rab7, Rab7a
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand GDP 1 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: C2221
Unit cell:
a: 64.5Å b: 103.2Å c: 51.7Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.187 0.247
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

25 review citations

Role of Rab GTPases in membrane traffic and cell physiology.
Hutagalung et al. (2011)
24 more

7 mentions without citation

Structural mechanisms for regulation of membrane traffic by rab GTPases.
Lee et al. (2009)
6 more