1vkx

X-ray diffraction
2.9Å resolution

CRYSTAL STRUCTURE OF THE NFKB P50/P65 HETERODIMER COMPLEXED TO THE IMMUNOGLOBULIN KB DNA

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-114723 (preferred)
Entry contents:
2 distinct polypeptide molecules
2 distinct DNA molecules
Macromolecules (4 distinct):
Transcription factor p65 Chain: A
Molecule details ›
Chain: A
Length: 273 amino acids
Theoretical weight: 30.98 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q04207 (Residues: 19-291; Coverage: 50%)
Gene names: Nfkb3, Rela
Sequence domains:
Structure domains:
Nuclear factor NF-kappa-B p50 subunit Chain: B
Molecule details ›
Chain: B
Length: 312 amino acids
Theoretical weight: 34.92 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P25799 (Residues: 39-350; Coverage: 32%)
Gene name: Nfkb1
Sequence domains:
Structure domains:
DNA (5'-D(*TP*GP*GP*GP*GP*AP*CP*TP*TP*TP*CP*C)-3') Chain: C
Molecule details ›
Chain: C
Length: 12 nucleotides
Theoretical weight: 3.67 KDa
DNA (5'-D(*AP*GP*GP*AP*AP*AP*GP*TP*CP*CP*CP*C)-3') Chain: D
Molecule details ›
Chain: D
Length: 12 nucleotides
Theoretical weight: 3.66 KDa

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P43212
Unit cell:
a: 106.61Å b: 106.61Å c: 206.56Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.208 0.32