› 1vlw

X-ray diffraction
2.3Å resolution

Crystal structure of 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase (TM0066) from Thermotoga maritima at 2.30 A resolution

Released:
DOI: 10.2210/pdb1vlw/pdb
PDB entry 1vlw coloured by chain, front view.
PDB entry 1vlw coloured by chain, side view.
PDB entry 1vlw coloured by chain, top view.
Source organism: Thermotoga maritima MSB8
Entry author: Joint Center for Structural Genomics (JCSG)

Function and Biology Details

Reactions catalysed: 
2-dehydro-3-deoxy-6-phosphate-D-gluconate = pyruvate + D-glyceraldehyde 3-phosphate
(4R)-4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo trimer
Assembly name:
PDBe Complex ID:
PDB-CPX-194434 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 217 amino acids
Theoretical weight: 23.73 KDa
Source organism: Thermotoga maritima MSB8
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9WXS1 (Residues: 1-205; Coverage: 100%)
Gene name: TM_0066
Sequence domains: KDPG and KHG aldolase
Structure domains: Aldolase class I

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.3
Spacegroup: C2221
Unit cell:
a: 79.543Å b: 113.194Å c: 128.397Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.177 0.221
Expression system: Escherichia coli

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