› 1vp6

X-ray diffraction
1.7Å resolution

M.loti ion channel cylic nucleotide binding domain

Released:
DOI: 10.2210/pdb1vp6/pdb
PDB entry 1vp6 coloured by chain, front view.
PDB entry 1vp6 coloured by chain, side view.
PDB entry 1vp6 coloured by chain, top view.
Source organism: Mesorhizobium loti
Primary publication:
Structural basis of ligand activation in a cyclic nucleotide regulated potassium channel.
Clayton GM, Silverman WR, Heginbotham L, Morais-Cabral JH
Cell 119 615-27 (2004)
PMID: 15550244

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189150 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclic nucleotide-gated potassium channel mll3241 Chains: A, C
Molecule details ›
Chains: A, C
Length: 138 amino acids
Theoretical weight: 14.58 KDa
Source organism: Mesorhizobium loti
Expression system: Escherichia coli
UniProt:
  • Canonical: Q98GN8 (Residues: 218-355; Coverage: 39%)
Gene name: mll3241
Sequence domains: Cyclic nucleotide-binding domain
Structure domains: Jelly Rolls

Ligands and Environments

2 bound ligands:
Ligand BR 16 x BR
Ligand CMP 2 x CMP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: P21
Unit cell:
a: 34.324Å b: 80.292Å c: 50.419Å
α: 90° β: 99.16° γ: 90°
R-values:
R R work R free
0.219 0.19 0.219
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Epac and PKA: a tale of two intracellular cAMP receptors.
Cheng et al. (2008)
10 more

15 mentions without citation

Structural basis of properties, mechanisms, and channelopathy of cyclic nucleotide-gated channels.
Hu et al. (2023)
14 more