› 1vyv

X-ray diffraction
3Å resolution

beta4 subunit of Ca2+ channel

Released:
DOI: 10.2210/pdb1vyv/pdb
PDB entry 1vyv coloured by chain, front view.
PDB entry 1vyv coloured by chain, side view.
PDB entry 1vyv coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels.
Chen YH, Li MH, Zhang Y, He LL, Yamada Y, Fitzmaurice A, Shen Y, Zhang H, Tong L, Yang J
Nature 429 675-80 (2004)
PMID: 15170217

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112609 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Voltage-dependent L-type calcium channel subunit beta-4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 359 amino acids
Theoretical weight: 40.38 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: D4A055 (Residues: 49-407; Coverage: 69%)
Gene name: Cacnb4
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 10 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 60.3Å b: 83.2Å c: 72.3Å
α: 90° β: 94.9° γ: 90°
R-values:
R R work R free
0.248 0.248 0.287
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

73 review citations

Voltage-gated calcium channels.
Catterall WA. (2011)
72 more

2 mentions without citation

The Ca2+ channel beta4c subunit interacts with heterochromatin protein 1 via a PXVXL binding motif.
Xu et al. (2011)
1 more