› 1w0b

Solution NMR

Solution structure of the human alpha-hemoglobin stabilizing protein (AHSP) P30A mutant

Released:
DOI: 10.2210/pdb1w0b/pdb
PDB entry 1w0b coloured by chain, ensemble of 20 models, front view.
PDB entry 1w0b coloured by chain, ensemble of 20 models, side view.
PDB entry 1w0b coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR structure of the alpha-hemoglobin stabilizing protein: insights into conformational heterogeneity and binding.
Santiveri CM, Pérez-Cañadillas JM, Vadivelu MK, Allen MD, Rutherford TJ, Watkins NA, Bycroft M
J Biol Chem 279 34963-70 (2004)
PMID: 15178680

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192741 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-hemoglobin-stabilizing protein Chain: A
Molecule details ›
Chain: A
Length: 102 amino acids
Theoretical weight: 11.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NZD4 (Residues: 2-102; Coverage: 99%)
Gene names: AHSP, EDRF, ERAF
Sequence domains: Alpha-haemoglobin stabilising protein
Structure domains: AHSP

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: CNS
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Hemoglobin and heme scavenging.
Ascenzi et al. (2005)
7 more

1 mention without citation

Kinetics of α-globin binding to α-hemoglobin stabilizing protein (AHSP) indicate preferential stabilization of hemichrome folding intermediate.
Mollan et al. (2012)