1w0t

X-ray diffraction
2Å resolution

hTRF1 DNA-binding domain in complex with telomeric DNA.

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-114755 (preferred)
Entry contents:
1 distinct polypeptide molecule
2 distinct DNA molecules
Macromolecules (3 distinct):
Telomeric repeat-binding factor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 53 amino acids
Theoretical weight: 6.64 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P54274 (Residues: 379-431; Coverage: 12%)
Gene names: PIN2, TERF1, TRBF1, TRF, TRF1
Sequence domains: Myb-like DNA-binding domain
Structure domains: Homeodomain-like
5'-D(*CP*TP*GP*TP*TP*AP*GP*GP*GP*TP *TP*AP*GP*GP*GP*TP*TP*AP*G)-3' Chain: C
Molecule details ›
Chain: C
Length: 19 nucleotides
Theoretical weight: 5.95 KDa
Source organism: Homo sapiens
Expression system: Not provided
5'-D(*TP*CP*TP*AP*AP*CP*CP*CP*TP*AP *AP*CP*CP*CP*TP*AP*AP*CP*A)-3' Chain: D
Molecule details ›
Chain: D
Length: 19 nucleotides
Theoretical weight: 5.68 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 38.443Å b: 72.36Å c: 116.706Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.252 0.252 0.273
Expression systems:
  • Escherichia coli
  • Not provided