Function and Biology Details
Reactions catalysed:
Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.
2'-deoxyadenosine + H(2)O = 2'-deoxyinosine + NH(3)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
Adenosine deaminase and Dipeptidyl peptidase 4 (preferred)
PDBe Complex ID:
PDB-CPX-151016 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (6 distinct):
Dipeptidyl peptidase 4
Molecule details ›
Chains: A, B, C, D
Length: 728 amino acids
Theoretical weight: 84.46 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
Sequence domains:
Structure domains:
Length: 728 amino acids
Theoretical weight: 84.46 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
- Canonical:
P27487 (Residues: 39-766; Coverage: 95%)
Sequence domains:
Structure domains:
Adenosine deaminase
Molecule details ›
Chains: E, F, G, H
Length: 357 amino acids
Theoretical weight: 40.46 KDa
Source organism: Bos taurus
UniProt:
Sequence domains: Adenosine deaminase
Structure domains: Metal-dependent hydrolases
Length: 357 amino acids
Theoretical weight: 40.46 KDa
Source organism: Bos taurus
UniProt:
- Canonical: P56658 (Residues: 1-357; Coverage: 98%)
Sequence domains: Adenosine deaminase
Structure domains: Metal-dependent hydrolases
Ligands and Environments
Experiments and Validation Details
X-ray source:
BESSY BEAMLINE 14.1
Spacegroup:
C2
Expression system: Spodoptera frugiperda
