› 1w3m

X-ray diffraction
1Å resolution

Crystal structure of tsushimycin

Released:
DOI: 10.2210/pdb1w3m/pdb
PDB entry 1w3m coloured by chain, front view.
PDB entry 1w3m coloured by chain, side view.
PDB entry 1w3m coloured by chain, top view.
Source organism: Actinoplanes friuliensis
Primary publication:
Structure of the lipopeptide antibiotic tsushimycin.
Bunkóczi G, Vértesy L, Sheldrick GM
Acta Crystallogr D Biol Crystallogr 61 1160-4 (2005)
PMID: 16041082

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162525 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TSUSHIMYCIN Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 11 amino acids
Theoretical weight: 1.11 KDa
Source organism: Actinoplanes friuliensis

Ligands and Environments

4 bound ligands:
Ligand LNG 12 x LNG
Ligand CA 25 x CA
Ligand CL 10 x CL
Ligand EOH 17 x EOH
3 modified residues:
Ligand VLL 12 x VLL
Ligand CPI 12 x CPI
Ligand VDL 12 x VDL

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P1
Unit cell:
a: 33.488Å b: 36.386Å c: 37.511Å
α: 65.64° β: 68.35° γ: 69.88°
R-values:
R R work R free
0.138 not available 0.171

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Citations

8 review citations

Natural products to drugs: natural product-derived compounds in clinical trials.
Butler MS. (2008)
7 more

3 mentions without citation

Identification and characterization of an inborn error of metabolism caused by dihydrofolate reductase deficiency.
Banka et al. (2011)
2 more