› 1w8k

X-ray diffraction
1.8Å resolution

Crystal structure of apical membrane antigen 1 from Plasmodium vivax

Released:
DOI: 10.2210/pdb1w8k/pdb
PDB entry 1w8k coloured by chain, front view.
PDB entry 1w8k coloured by chain, side view.
PDB entry 1w8k coloured by chain, top view.
Source organism: Plasmodium vivax
Primary publication:
Crystal structure of the malaria vaccine candidate apical membrane antigen 1.
Pizarro JC, Vulliez-Le Normand B, Chesne-Seck ML, Collins CR, Withers-Martinez C, Hackett F, Blackman MJ, Faber BW, Remarque EJ, Kocken CH, Thomas AW, Bentley GA
Science 308 408-11 (2005)
PMID: 15731407

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apical merozoite antigen 1 Chain: A
Molecule details ›
Chain: A
Length: 447 amino acids
Theoretical weight: 51.6 KDa
Source organism: Plasmodium vivax
Expression system: Komagataella pastoris
UniProt:
  • Canonical: O61130 (Residues: 43-487; Coverage: 79%)
Gene name: AMA1
Sequence domains: Apical membrane antigen 1
Structure domains: Hepatocyte Growth Factor

Ligands and Environments

1 bound ligand:
Ligand IMD 1 x IMD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C2
Unit cell:
a: 150.03Å b: 53.76Å c: 60.29Å
α: 90° β: 113.18° γ: 90°
R-values:
R R work R free
0.222 0.219 0.269
Expression system: Komagataella pastoris

Quick links

Citations

24 review citations

Invasion of red blood cells by malaria parasites.
Cowman et al. (2006)
23 more

17 mentions without citation

Microneme proteins in apicomplexans.
Carruthers et al. (2008)
16 more