› 1wbm

X-ray diffraction
2Å resolution

HIV-1 protease in complex with symmetric inhibitor, BEA450

Released:
DOI: 10.2210/pdb1wbm/pdb
PDB entry 1wbm coloured by chain, front view.
PDB entry 1wbm coloured by chain, side view.
PDB entry 1wbm coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Entry authors: Lindberg J, Unge T

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185839 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidase A2 domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 99 amino acids
Theoretical weight: 10.8 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8Q3H0 (Residues: 1-99; Coverage: 100%)
Gene name: pol
Sequence domains: Retroviral aspartyl protease
Structure domains: Acid Proteases

Ligands and Environments

1 bound ligand:
Ligand BLL 1 x BLL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711
Spacegroup: P21212
Unit cell:
a: 58.835Å b: 86.472Å c: 46.997Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.217 0.244
Expression system: Escherichia coli

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