› 1wct

Solution NMR

A NOVEL CONOTOXIN FROM CONUS TEXTILE WITH UNUSUAL POST-TRANSLATIONAL MODIFICATIONS REDUCES PRESYNAPTIC CALCIUM INFLUX, NMR, 1 STRUCTURE, GLYCOSYLATED PROTEIN

Released:
DOI: 10.2210/pdb1wct/pdb
PDB entry 1wct coloured by chain, front view.
PDB entry 1wct coloured by chain, side view.
PDB entry 1wct coloured by chain, top view.
Source organism: Conus textile
Primary publication:
A conotoxin from Conus textile with unusual posttranslational modifications reduces presynaptic Ca2+ influx.
Rigby AC, Lucas-Meunier E, Kalume DE, Czerwiec E, Hambe B, Dahlqvist I, Fossier P, Baux G, Roepstorff P, Baleja JD, Furie BC, Furie B, Stenflo J
Proc Natl Acad Sci U S A 96 5758-63 (1999)
PMID: 10318957

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160550 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Epsilon-conotoxin TxVA Chain: A
Molecule details ›
Chain: A
Length: 13 amino acids
Theoretical weight: 1.57 KDa
Source organism: Conus textile
UniProt:
  • Canonical: P81755 (Residues: 51-63; Coverage: 27%)

Ligands and Environments

Carbohydrate polymer : NEW Components: NGA, GAL
Carbohydrate polymer
No bound ligands
3 modified residues:
Ligand CGU 2 x CGU
Ligand BTR 1 x BTR
Ligand HYP 1 x HYP

Experiments and Validation Details

Entry percentile scores
Refinement method: DGII

Quick links

Citations

15 review citations

Conus venoms: a rich source of novel ion channel-targeted peptides.
Terlau et al. (2004)
14 more

3 mentions without citation

Conotoxin gene superfamilies.
Robinson et al. (2014)
2 more