› 1wd9

X-ray diffraction
2.6Å resolution

Calcium bound form of human peptidylarginine deiminase type4 (PAD4)

Released:
DOI: 10.2210/pdb1wd9/pdb
PDB entry 1wd9 coloured by chain, front view.
PDB entry 1wd9 coloured by chain, side view.
PDB entry 1wd9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for Ca(2+)-induced activation of human PAD4.
Arita K, Hashimoto H, Shimizu T, Nakashima K, Yamada M, Sato M
Nat Struct Mol Biol 11 777-83 (2004)
PMID: 15247907

Function and Biology Details

Reaction catalysed: 
Protein L-arginine + H(2)O = protein L-citrulline + NH(3)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193952 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein-arginine deiminase type-4 Chain: A
Molecule details ›
Chain: A
Length: 670 amino acids
Theoretical weight: 74.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9UM07 (Residues: 1-663; Coverage: 100%)
Gene names: PAD4, PADI4, PADI5, PDI5
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CA 5 x CA
Ligand SO4 3 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-D
Spacegroup: C2
Unit cell:
a: 146.389Å b: 60.094Å c: 115.339Å
α: 90° β: 124.37° γ: 90°
R-values:
R R work R free
0.228 0.224 0.269
Expression system: Escherichia coli BL21(DE3)

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Citations

63 review citations

Citrullination: a posttranslational modification in health and disease.
György et al. (2006)
62 more

9 mentions without citation

Chemical biology of protein arginine modifications in epigenetic regulation.
Fuhrmann et al. (2015)
8 more