› 1wdg

X-ray diffraction
2.06Å resolution

crystal structure of MHV spike protein fusion core

Released:
DOI: 10.2210/pdb1wdg/pdb
Model geometry
Fit model/data
PDB entry 1wdg coloured by chain, front view.
PDB entry 1wdg coloured by chain, side view.
PDB entry 1wdg coloured by chain, top view.
Source organism: Murine hepatitis virus strain A59
Primary publication:
Structural basis for coronavirus-mediated membrane fusion. Crystal structure of mouse hepatitis virus spike protein fusion core.
Xu Y, Liu Y, Lou Z, Qin L, Li X, Bai Z, Pang H, Tien P, Gao GF, Rao Z
OpenAccess logo J Biol Chem 279 30514-22 (2004)
PMID: 15123674

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo hexamer
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145717 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Spike protein S2' Chains: A, B
Molecule details ›
Chains: A, B
Length: 94 amino acids
Theoretical weight: 9.89 KDa
Source organism: Murine hepatitis virus strain A59
Expression system: Escherichia coli
UniProt:
  • Canonical: P11224 (Residues: 969-1017, 1032-1055, 1056-1059; Coverage: 6%)
Gene names: 3, S
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU
Spacegroup: R3
Unit cell:
a: 51.6Å b: 51.6Å c: 198.2Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.269 0.26 0.298
Expression system: Escherichia coli

Quick links

Citations

25 review citations

Structure, Function, and Evolution of Coronavirus Spike Proteins.
Li F. (2016)
24 more

5 mentions without citation

From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses.
Hilgenfeld et al. (2013)
4 more