› 1wnh

X-ray diffraction
1.83Å resolution

Crystal structure of mouse Latexin (tissue carboxypeptidase inhibitor)

Released:
DOI: 10.2210/pdb1wnh/pdb
PDB entry 1wnh coloured by chain, front view.
PDB entry 1wnh coloured by chain, side view.
PDB entry 1wnh coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1.
Aagaard A, Listwan P, Cowieson N, Huber T, Ravasi T, Wells CA, Flanagan JU, Kellie S, Hume DA, Kobe B, Martin JL
Structure 13 309-17 (2005)
PMID: 15698574

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159711 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Latexin Chain: A
Molecule details ›
Chain: A
Length: 225 amino acids
Theoretical weight: 25.84 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P70202 (Residues: 1-222; Coverage: 100%)
Gene name: Lxn
Sequence domains:
Structure domains: Nuclear Transport Factor 2; Chain: A,

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P43212
Unit cell:
a: 103.9Å b: 103.9Å c: 60Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.211 0.237
Expression system: Escherichia coli

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Citations

9 review citations

Towards novel anti-cancer strategies based on cystatin function.
Keppler D. (2006)
8 more