› 1wpd

Solution NMR

Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins

Released:
DOI: 10.2210/pdb1wpd/pdb
PDB entry 1wpd coloured by chain, ensemble of 20 models, front view.
PDB entry 1wpd coloured by chain, ensemble of 20 models, side view.
PDB entry 1wpd coloured by chain, ensemble of 20 models, top view.
Source organism: Heterometrus spinifer
Primary publication:
Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins.
Regaya I, Beeton C, Ferrat G, Andreotti N, Darbon H, De Waard M, Sabatier JM
J Biol Chem 279 55690-6 (2004)
PMID: 15498765

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160448 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Potassium channel toxin alpha-KTx 6.2 Chain: A
Molecule details ›
Chain: A
Length: 34 amino acids
Theoretical weight: 3.8 KDa
Source organism: Heterometrus spinifer
Expression system: Homo sapiens
UniProt:
  • Canonical: P80719 (Residues: 1-34; Coverage: 100%)
Sequence domains: Scorpion short toxin, BmKK2

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, molecular dynamics
Expression system: Homo sapiens

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Citations

5 review citations

Potassium channel blockers in multiple sclerosis: neuronal Kv channels and effects of symptomatic treatment.
Judge et al. (2006)
4 more

1 mention without citation

New tricks of an old pattern: structural versatility of scorpion toxins with common cysteine spacing.
Saucedo et al. (2012)