› 1wq9

X-ray diffraction
2Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159244 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Snake venom vascular endothelial growth factor toxin VR-1 Chain: A
Molecule details ›
Chain: A
Length: 96 amino acids
Theoretical weight: 10.97 KDa
Source organism: Daboia russelii russelii
UniProt:
  • Canonical: P67861 (Residues: 25-119; Coverage: 79%)
Sequence domains: PDGF/VEGF domain
Structure domains: Cystine-knot cytokines
Snake venom vascular endothelial growth factor toxin VR-1 Chain: B
Molecule details ›
Chain: B
Length: 96 amino acids
Theoretical weight: 10.95 KDa
Source organism: Daboia russelii russelii
UniProt:
  • Canonical: P67861 (Residues: 25-119; Coverage: 79%)
Sequence domains: PDGF/VEGF domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PCA 1 x PCA

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-18B, PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: P21212
Unit cell:
a: 90.348Å b: 48.961Å c: 54.214Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.206 0.206 0.252

Quick links

Citations

22 review citations

VEGF receptor signalling - in control of vascular function.
Olsson et al. (2006)
21 more

6 mentions without citation

A Structural Overview of Vascular Endothelial Growth Factors Pharmacological Ligands: From Macromolecules to Designed Peptidomimetics.
Ye et al. (2021)
5 more