› 1wqk

Solution NMR

Solution structure of APETx1, a specific peptide inhibitor of human Ether-a-go-go-related gene potassium channels from the venom of the sea anemone Anthopleura elegantissima: a new fold for an HERG toxin

Released:
DOI: 10.2210/pdb1wqk/pdb
PDB entry 1wqk coloured by chain, ensemble of 25 models, front view.
PDB entry 1wqk coloured by chain, ensemble of 25 models, side view.
PDB entry 1wqk coloured by chain, ensemble of 25 models, top view.
Source organism: Anthopleura elegantissima
Primary publication:
Solution structure of APETx1 from the sea anemone Anthopleura elegantissima: a new fold for an HERG toxin.
Chagot B, Diochot S, Pimentel C, Lazdunski M, Darbon H
Proteins 59 380-6 (2005)
PMID: 15726634

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158271 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kappa-actitoxin-Ael2a Chain: A
Molecule details ›
Chain: A
Length: 42 amino acids
Theoretical weight: 4.56 KDa
Source organism: Anthopleura elegantissima
UniProt:
  • Canonical: P61541 (Residues: 1-42; Coverage: 100%)
Sequence domains: Potassium-channel blocking toxin
Structure domains: Anthopleurin-A

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores

Quick links

Citations

10 review citations

hERG K(+) channels: structure, function, and clinical significance.
Vandenberg et al. (2012)
9 more

7 mentions without citation

Sea anemone (Cnidaria, Anthozoa, Actiniaria) toxins: an overview.
Frazão et al. (2012)
6 more