Function and Biology Details
Reactions catalysed:
Phosphoenolpyruvate + N-acetyl-D-mannosamine + H(2)O = phosphate + N-acetylneuraminate
Phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H(2)O = N-acylneuraminate 9-phosphate + phosphate
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Sialic acid synthase (preferred)
PDBe Complex ID:
PDB-CPX-192537 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sialic acid synthase
Molecule details ›
Chain: A
Length: 79 amino acids
Theoretical weight: 8.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
Sequence domains: SAF domain
Structure domains: Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain
Length: 79 amino acids
Theoretical weight: 8.27 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
- Canonical:
Q9NR45 (Residues: 294-359; Coverage: 18%)
Sequence domains: SAF domain
Structure domains: Antifreeze-like/N-acetylneuraminic acid synthase C-terminal domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Refinement method:
torsion angle dynamics
Expression system: Not provided
