› 1x0n

Solution NMR

NMR structure of growth factor receptor binding protein SH2 domain complexed with the inhibitor

Released:
DOI: 10.2210/pdb1x0n/pdb
PDB entry 1x0n coloured by chain, ensemble of 20 models, front view.
PDB entry 1x0n coloured by chain, ensemble of 20 models, side view.
PDB entry 1x0n coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Ogura K, Shiga T, Yuzawa S, Yokochi M, Burke TR, Inagaki F

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158852 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth factor receptor-bound protein 2 Chain: A
Molecule details ›
Chain: A
Length: 104 amino acids
Theoretical weight: 12.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P62993 (Residues: 58-159; Coverage: 47%)
Gene names: ASH, GRB2
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

1 bound ligand:
Ligand DTF 1 x DTF
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

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