› 1x9v

Solution NMR

Dimeric structure of the C-terminal domain of Vpr

Released:
DOI: 10.2210/pdb1x9v/pdb
PDB entry 1x9v coloured by chain, ensemble of 10 models, front view.
PDB entry 1x9v coloured by chain, ensemble of 10 models, side view.
PDB entry 1x9v coloured by chain, ensemble of 10 models, top view.
Source organism: HIV-1 M:B_89.6
Primary publication:
The C-terminal domain of the HIV-1 regulatory protein Vpr adopts an antiparallel dimeric structure in solution via its leucine-zipper-like domain.
Bourbigot S, Beltz H, Denis J, Morellet N, Roques BP, Mély Y, Bouaziz S
Biochem J 387 333-41 (2005)
PMID: 15571493

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180927 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein Vpr Chains: A, B
Molecule details ›
Chains: A, B
Length: 45 amino acids
Theoretical weight: 5.26 KDa
Source organism: HIV-1 M:B_89.6
Expression system: Not provided
UniProt:
  • Canonical: Q73369 (Residues: 52-96; Coverage: 47%)
Gene name: vpr
Sequence domains: VPR/VPX protein
Structure domains: VpR/VpX protein, C-terminal domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: restrained simulated annealing, molecular dynamics, energy minimization
Expression system: Not provided

Quick links

Citations

4 review citations

The Vpr protein from HIV-1: distinct roles along the viral life cycle.
Le Rouzic et al. (2005)
3 more

3 mentions without citation

The C-terminal domain of the HIV-1 regulatory protein Vpr adopts an antiparallel dimeric structure in solution via its leucine-zipper-like domain.
Bourbigot et al. (2005)
2 more